diff --git a/modules/caddyhttp/reverseproxy/reverseproxy.go b/modules/caddyhttp/reverseproxy/reverseproxy.go
index 276616b4..cc6b530c 100644
--- a/modules/caddyhttp/reverseproxy/reverseproxy.go
+++ b/modules/caddyhttp/reverseproxy/reverseproxy.go
@@ -109,6 +109,11 @@ type Handler struct {
 	// response is recognized as a streaming response, or if its
 	// content length is -1; for such responses, writes are flushed
 	// to the client immediately.
+	//
+	// Normally, a request will be canceled if the client disconnects
+	// before the response is received from the backend. If explicitly
+	// set to -1, client disconnection will be ignored and the request
+	// will be completed to help facilitate low-latency streaming.
 	FlushInterval caddy.Duration `json:"flush_interval,omitempty"`
 
 	// A list of IP ranges (supports CIDR notation) from which
@@ -757,6 +762,15 @@ func (h *Handler) reverseProxy(rw http.ResponseWriter, req *http.Request, origRe
 		req = req.WithContext(httptrace.WithClientTrace(req.Context(), trace))
 	}
 
+	// if FlushInterval is explicitly configured to -1 (i.e. flush continuously to achieve
+	// low-latency streaming), don't let the transport cancel the request if the client
+	// disconnects: user probably wants us to finish sending the data to the upstream
+	// regardless, and we should expect client disconnection in low-latency streaming
+	// scenarios (see issue #4922)
+	if h.FlushInterval == -1 {
+		req = req.WithContext(ignoreClientGoneContext{req.Context(), h.ctx.Done()})
+	}
+
 	// do the round-trip; emit debug log with values we know are
 	// safe, or if there is no error, emit fuller log entry
 	start := time.Now()
@@ -1374,6 +1388,19 @@ type handleResponseContext struct {
 	isFinalized bool
 }
 
+// ignoreClientGoneContext is a special context.Context type
+// intended for use when doing a RoundTrip where you don't
+// want a client disconnection to cancel the request during
+// the roundtrip. Set its done field to a Done() channel
+// of a context that doesn't get canceled when the client
+// disconnects, such as caddy.Context.Done() instead.
+type ignoreClientGoneContext struct {
+	context.Context
+	done <-chan struct{}
+}
+
+func (c ignoreClientGoneContext) Done() <-chan struct{} { return c.done }
+
 // proxyHandleResponseContextCtxKey is the context key for the active proxy handler
 // so that handle_response routes can inherit some config options
 // from the proxy handler.